Proactive Topical Maintenance Treatment of Psoriasis: Subanalysis of Canadian Patients in the Phase III PSO-LONG Trial
Bibliographic record
Abstract
Plaque psoriasis is a chronic disease that requires long-term management.<sup> </sup> Although topical therapies are a first-line treatment, maintaining long-term disease control is a challenge.<sup> , </sup> Topical psoriasis treatment has traditionally relied on a reactive approach to disease flares rather than a proactive long-term approach involving regular application of therapy to previously affected skin areas after they have healed.<sup> , </sup> The PSO-LONG phase III trial demonstrated the long-term efficacy and safety of twice-weekly calcipotriol 0.005%/betamethasone dipropionate 0.064% (Cal/BD) foam as maintenance treatment for psoriasis.<sup> </sup> This proactive regimen significantly delayed time to first relapse, reduced relapses, and increased time in remission compared to reactive management, with no new safety signals or skin atrophy. Regional differences in patient demographics and disease characteristics, as well as standards of care, may influence the effect size of treatment interventions.<sup> </sup> To assess whether the results of the multinational PSO-LONG trial are generalizable to the Canadian psoriasis population, we analyzed the long-term safety and efficacy of proactive Cal/BD foam in the subset of Canadian subjects in the PSO-LONG trial.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.002 | 0.002 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.002 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.023 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".