Endovascular treatment combined with eptifibatide in patients with acute ischemic stroke: a prospective, multicenter study
Bibliographic record
Abstract
Objective To explore the efficacy and safety of endovascular treatment (EVT) combined with eptifibatide in the treatment of acute ischemic stroke. Methods This study enrolled the 102 acute ischemic stroke patients at 15 centers in China received EVT combined with eptifibatide from April 2019 to March 2020. The primary efficacy outcome was the reperfusion rate of blood vessels within 24 h after treatment [modified Thrombolysis in Cerebral Infarction (mTICI) grade ≥ 2b], while the secondary efficacy outcomes were the complete reperfusion (mTICI grade 3) rate of blood vessels within 24 h after treatment and the 3⁃month neurological function prognosis [modified Rankin Scale (mRS) score ≤ 2]; the incidence of symptomatic intracranial hemorrhage (sICH) within 48 h after treatment was the primary safety outcome, while the incidence of intracranial hemorrhage (ICH), parenchymal hemorrhage (PH), hemorrhagic infarction (HI), remote parenchymal hemorrhage (rPH), intraventricular hemorrhage (IVH), and subarachnoid hemorrhage (SAH) within 48 h, and 3 ⁃ month mortality after treatment were secondary safety outcomes. Univariate and multivariate stepwise Logistic regression analyses were used to screen for the influencing factors of prognosis after EVT combined with eptifibatide for acute ischemic stroke. Results The successful reperfusion (mTICI grade ≥ 2b) rate and complete reperfusion (mTICI grade 3) rate of blood vessels within 24 h after treatment were 86.27% (88/102) and 68.63% (70/102), respectively. The good prognosis (mRS score ≤ 2) rate at 3⁃month after treatment was 54.90% (56/102). The incidence of sICH within 48 h after treatment was 4.90% (5/102). The incidence of ICH was 19.61% (20/102), PH was 11.76% (12/102), HI was 5.88% (6/102), rPH was 1.96% (2/102), IVH was 3.92% (4/102), and there was no SAH within 48 h after treatment. The mortality rate at 3⁃month after treatment was 16.67% (17/102). Logistic regression analysis showed that an admission National Institutes of Health Stroke Scale (NIHSS) score of > 15 was a risk factor for poor prognosis in patients with acute ischemic stroke after EVT combined with eptifibatide (OR = 0.118, 95%CI: 0.046-0.307; P = 0.000), while an Alberta Stroke Program Early CT Score (ASPECTS) of ≥ 6 was a protective factor for good prognosis (OR = 5.871, 95%CI: 1.812-19.020; P = 0.003). Conclusions The combined regimen of eptifibatide and EVT studied in this trial was effective and safe. Optimal administration method and randomized controlled trial are need to be further justified.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".