Additional file 1 of Time spent above optimal cerebral perfusion pressure is not associated with failure to improve in outcome in traumatic brain injury
Bibliographic record
Abstract
Additional file 1: Appendix A. Mann–Whitney U/Chi-Square Testing of Physiologic and Demographic Data for Alive/Dead and Favorable/Unfavorable at 1 month. Appendix B. Mann–Whitney U/Chi-Square Testing of Physiologic and Demographic Data for Alive/Dead and Favorable/Unfavorable at 3 months. Appendix C. Mann–Whitney U/Chi-Square Testing of Physiologic and Demographic Data for Alive/Dead and Favorable/Unfavorable at 6 months. Appendix D. Mann–Whitney U/Chi-Square Testing of Physiologic and Demographic Data for Improved/Not Improved (3–6 months). Appendix E. Mann–Whitney U/Chi-Square Testing of Physiologic and Demographic Data for Improved/Not Improved (1–3 months) with Those Who Died (GOSE = 1) Removed. Appendix F. Mann–Whitney U/Chi-Square Testing of Physiologic and Demographic Data for Improved/Not Improved (3–6 months) with Those Who Died (GOSE = 1) Removed. Appendix G. Mann–Whitney U/Chi-Square Testing of Physiologic and Demographic Data for Improved/Not Improved (1–6 months) with Those Who Died (GOSE = 1) Removed. Appendix H. Mann–Whitney U/Chi-Square Testing of Physiologic and Demographic Data for Improved/Not Improved (1–3 months) with Patients Trichotomized by Age. Appendix I. Mann–Whitney U/Chi-Square Testing of Physiologic and Demographic Data for Improved/Not Improved (3–6 months) with Patients Trichotomized by Age. Appendix J. Mann–Whitney U/Chi-Square Testing of Physiologic and Demographic Data for Improved/Not Improved (1–6 months) with Patients Trichotomized by Age. Appendix K. Histograms Comparing Improved and Not Improved Patients for % time with ΔCPPopt above/below 10 mmHg. Appendix L. Univariate Models of Cerebrovascular Reactivity Measures for Transition in Outcome with Those Who Died (GOSE = 1) Removed. Appendix M. Univariate Models of Cerebrovascular Reactivity Measures for Transition in Outcome with Patients Trichotomized by Age. Appendix N. Multivariable Models of Cerebrovascular Reactivity Measures + IMPACT Core ± CT ± ICP > 20 or 22 mmHg for Transition in Outcome from 1 to 3 months. Appendix O. Multivariable Models of Cerebrovascular Reactivity Measures + IMPACT Core ± CT ± ICP > 20 or 22 mmHg for Transition in Outcome from 3 to 6 months. Appendix P. Multivariable Models of Cerebrovascular Reactivity Measures + IMPACT Core ± CT ± ICP > 20 or 22 mmHg for Transition in Outcome from 1 to 6 months. Appendix Q. Multivariable Models of Cerebrovascular Reactivity Measures + IMPACT Core ± CT ± ICP > 20 or 22 mmHg for Transition in Outcome from 1 to 3 months with Those Who Died (GOSE = 1) Removed. Appendix R. Multivariable Models of Cerebrovascular Reactivity Measures + IMPACT Core ± CT ± ICP > 20 or 22 mmHg for Transition in Outcome from 3 to 6 months with Those Who Died (GOSE = 1) Removed. Appendix S. Multivariable Models of Cerebrovascular Reactivity Measures + IMPACT Core ± CT ± ICP > 20 or 22 mmHg for Transition in Outcome from 1 to 6 months with Those Who Died (GOSE = 1) Removed. Appendix T. Multivariable Models of Cerebrovascular Reactivity Measures for Transition in Outcome from 1 to 3 months with Patients Trichotomized by Age. Appendix U. Multivariable Models of Cerebrovascular Reactivity Measures for Transition in Outcome from 3 to 6 months with Patients Trichotomized by Age. Appendix V. Multivariable Models of Cerebrovascular Reactivity Measures for Transition in Outcome from 1 to 6 months with Patients Trichotomized by Age. Appendix W. Added Variance in Transition in Outcome of Cerebrovascular Reactivity Measures Over IMPACT Core ± CT ± ICP > 20 or 22 mmHg with Those Who Died (GOSE = 1) Removed. Appendix X. Added Variance in Transition in Outcome of Cerebrovascular Reactivity Measures Over IMPACT Core ± CT ± ICP > 20 or 22 mmHg with Patients Trichotomized by Age. Appendix Y. Extended Discussion. Appendix Z. Graphical Illustration of the Relationships Between ICP and Cerebrovascular Reactivity
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.946 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; both teacher heads agree on what is shown here.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".