ROLE OF GUT MICROBIOTA IN THE EPISODIC NATURE OF SYMPTOMS IN IRRITABLE BOWEL SYNDROME
Bibliographic record
Abstract
Irritable Bowel Syndrome (IBS) is a gut-brain-axis disorder with a prevalence of 5.8% in Canada and 3.8% globally. Despite evidence suggesting complex interactions among neural, immune, and epithelial cells, influenced by factors such as diet, microbiota, and stress, the pathophysiology of IBS remains incompletely understood. Key knowledge gaps include the irregular nature of symptoms and the specific bacterial taxa responsible for symptom generation. Therefore, this thesis aims to perform an integrated analysis of a longitudinal study to investigate the relationship between IBS symptom dynamics, gut microbiota composition, and metabolite profiles, to determine whether temporal changes in microbiota predict or drive IBS symptoms. Clustering analysis identified distinct patterns in symptom occurrence and progression, categorizing samples into clusters that captured changes in both gut and mood symptoms, and distinguishing between symptom flares and remission. Subjects with constipation-predominant IBS exhibited consistently higher levels of symptoms while diarrhea-predominant IBS subjects showed varying symptom levels among abnormal stool weeks and normal stool weeks. Examining parallel changes in symptom scores and microbiota beta diversity over time, we found a significant correlation between the two in only 25% of IBS subjects in our cohort. This suggests a potential link between microbiota composition and symptom variability in specific subsets of patients, highlighting the heterogeneity in the microbiota-symptom relationship. Integrated microbiota-metabolite analysis revealed signatures linked to IBS subtypes, with bacteria such as Lachnoclostridium and Olsenella ,and metabolites like chenodeoxycholic acid among others identified as key nodes in network analysis. In conclusion, this study offers comprehensive insights into the episodic nature and heterogeneity of IBS, revealing dynamic symptom patterns and persistent burdens across subtypes. The findings highlight the complex relationship between microbiota composition changes and symptom variation, as well as the microbiota-metabolite axis in IBS patients.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".