The association between Campylobacter jejuni infection and Guillain Barre syndrome
Bibliographic record
Abstract
Infection with Campylobacter jejuni, a common enteric pathogen, may be one of the major causes of Guillain Barrd Syndrome (GBS), a neurological disease of humans. Antibodies produced in rabbits against different Campylobacter jejuni strains, commonly incriminated in Guillain Barrd Syndrome (GBS) were tested in two experimental systems to quantify their effects on peripheral nerve function and neurons. The effect of these antiserum antibodies on peripheral nerve function was determined (in vivo) in Sprague-Dawley rats using electrophysiological measurements of the femoral nerve prior to injection of antiserum (Day 0) and on Days 2, 7, and 14 after injection. The results indicated that serum antibodies against certain strains of C. jejuni affect peripheral nerve function and react immunologically in particular neural cell lines. To test the effects of these antibodies on neurons, 7 cultured human neural cell lines were evaluated for reactivity with 7 different anti-C. jejuni sera by indirect immunofluorescence. To determine the prevalence of GBS and possible sources of organisms associated with GBS in Maritime Canada and to assess whether certain strains of C. jejuni are significantly associated with GBS, a retrospective study of GBS patients and suitable controls was completed. Differences in 10 patients and matched control groups were analysed. (Abstract shortened by UMI.).
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".