Curvature-density functional theory of shape transformation in vesicles of two-component lipid systems / by Ian MacKay.
Bibliographic record
Abstract
The shape transformations and composition variation of two-component model lipid membrane isolated vesicles are studied.These are studied as aggregates in low concentration solutions so that the vesicles are isolated from each other and interaction effects can be ignored.The seminal work of Julicher and Lipowsky derived a curvaturefunctional free energy, which has predicted or verified many of the experimentally observed behaviors of model vesicles.One aspect that has not been well explored is the composition variation of the liquid domains.In this work, the theory of Julicher and Lipowsky is modified to include couplings between the curvature and composition but the shape of the vesicle is restricted to include only ellipsoids of varying degree of eccentricity and constant area.We also introduce a free energy to describe bilayered micelles ("bicelles").The energetics of this structure is studied and phase diagrams are found for various vesicle-bicelle transitions.The properties of liquid domains, including compositional variations with temperature are also discussed.These results are then compared to experiments on vesicles and bicelles using small angle neutron scattering and nuclear magnetic resonance.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".