Enantioselective Rhodium-catalyzed Hydroacylation of Alkenes and Ketones & Silver-catalyzed Hydroamination of Cyclopropenes
Bibliographic record
Abstract
Due to the scarcity of energy resources that we are facing today, there is an increasing need for new methodology developments that are green and sustainable while minimizing unnecessary substrate pre-functionalization, by-product formation and waste generation. In this context, asymmetric rhodium-catalyzed hydroacylation is an atom-economical method for the preparation of chiral ketone derivatives from aldehyde and olefin precursors. This transformation is also applicable to keto-aldehyde precursors en route to chiral lactones. This dissertation describes the development of three specific methodologies, namely: 1) the synthesis of enantioenriched cyclopropyl ketones by enantio- and diastereoselective intermolecular rhodium-catalyzed hydroacylation of cyclopropenes, 2) the synthesis of enantioenriched phthalides by enantioselective rhodium-catalyzed intramolecular hydroacylation of ketones, and 3) the synthesis of tertiary branched allylic amines by silver-catalyzed ring-opening hydroamination of cyclopropenes.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".