Perioperative infusion of amino acids: the effect of epidural blockade: An integrated analysis of glucose and protein metabolism with stable isotopes kinetics
Bibliographic record
Abstract
The present project investigated the effect of epidural blockade with local anesthetic on the catabolic stress response during and after abdominal surgery in patients receiving intravenous amino acid infusion.The kinetics of protein and glucose metabolism were determined by an isotope dilution technique using stable isotope L-[1-13C]leucine and [6,6-2H2]glucose.The intraoperative provision of amino acids induced a positive protein balance independently of the anesthetic technique.In addition, amino acids supplementation did not influence gluconeogenesis, while whole body glucose uptake decreased independently of the type of anesthesia used.The postoperative infusion of amino acids inhibited protein breakdown and stimulates protein synthesis, thus rendering protein balance positive regardless of analgesic.The effect of amino acids on postoperative glucose metabolism was characterized by a decrease glucose clearance indicating a state of insulin resistance and by a decrease in endogenous glucose production.V V Résumé Ce projet a étudié l'effet d'un bloc péridural avec agents anesthétiques locaux sur la réponse catabolique au stress durant et après une chirurgie abdominale chez des patients recevant une infusion d'acides aminés.La cinétique du métabolisme protéique et du glucose a été évaluée a l'aide des isotopes stables L-[1-13C]leucine et [6,6-2H2]glucose.L'infusion d'acides aminés pendant l'intervention a induit une balance protéique positive indépendamment de la technique anesthétique employée.La production endogène du glucose n'a pas été modifiée par l'infusion d'acides aminés, par contre, celle-ci a diminuée la prise périphérique du glucose indépendamment de la technique anesthétique employée.L'infusion d'acides aminés après l'intervention a empêché la dégradation protéique et a stimulé la synthèse protéique, résultant en une balance protéique positive, indépendamment de la technique anesthétique employée.L'effet de l'infusion d'acides aminés sur le métabolisme glucidique postopératoire a été caractérisé par la diminution de la prise périphérique du glucose, indiquant le développement d'un état de résistance à l'insuline (en périphérie) et aussi par la diminution de la production endogène du glucose.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.012 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".