Efficacy Analysis of TACE Combined with Lenvatinib and PD-1 Inhibitors in the Treatment of Hepatitis B Virus-Related Unresectable Hepatocellular Carcinoma
Bibliographic record
Abstract
Jin Yu,1 Yuan Zhu,1 Shiyi Zhao,1 Xiaogang Li2 1School of Medicine, Wuhan University of Science and Technology, Wuhan, 430065, People’s Republic of China; 2Department of Biliary and Pancreatic Surgery, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, 441021, People’s Republic of ChinaCorrespondence: Xiaogang Li, Research Focus: Hepatobiliary and Pancreatic Surgery, Tel +86 13886298666, Email 15827898579@163.comBackground: To explore the impact of hepatitis B virus (HBV) DNA on the efficacy of triple therapy [transarterial chemoembolization (TACE), lenvatinib, and programmed cell death protein-1 (PD-1) inhibitors] in the treatment of HBV-related unresectable hepatocellular carcinoma (u-HCC).Methods: We retrospectively collected clinical data on triple therapy for HBV-related u-HCC from January 2020 to January 2024 at Xiangyang Central Hospital. Patients with HBV-DNA ≤ 1000 IU/mL were designated the low HBV-DNA level group, and patients with HBV-DNA > 1000 IU/mL were designated the high HBV-DNA level group. The primary endpoint of this study was to compare the progression-free survival (PFS) and overall survival (OS), between the low HBV-DNA level and high HBV-DNA level groups. The secondary endpoint compares the objective response rate (ORR) between the two groups.Results: Data from 95 patients were obtained, with 41 patients in the low HBV-DNA level group and 54 patients in the high HBV-DNA level group. After treatment, the median PFS and OS was 10.00 months and 25.03 months in the low HBV-DNA level group and 7.23 months and 15.00 months in the high HBV-DNA level group (all P < 0.05). The low HBV-DNA level group had an ORR of 30 patients, and the high HBV-DNA level group had 32 patients (85.37% vs 64.81%, P = 0.024).Conclusion: HBV-DNA > 1000 IU/mL is associated with poorer prognosis in patients with HBV-related u-HCC treated with triple therapy. In triple therapy for HBV-related u-HCC, HBV-DNA levels above 1000 IU/mL should be actively controlled.Keywords: hepatocellular carcinoma, hepatitis B virus, transarterial chemoembolization, immunotherapy
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.003 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".