Incretin-based drugs and the incidence of endometrial cancer among patients with type 2 diabetes
Bibliographic record
Abstract
Background: Incretin-based drugs, which include glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and dipeptidyl peptidase-4 (DPP-4) inhibitors, are second-to third-line antihyperglycemic drugs used to treat type 2 diabetes.Type 2 diabetes is a major risk factor for the development of endometrial cancer.There is novel experimental evidence proposing that incretin-based drugs may attenuate the growth of endometrial cancer cells.Laboratory studies have found that treating human endometrial cells with an incretin-based drug can slow tumour growth rates in a dose-dependent manner.However, there is a paucity of research on the association between the use of incretin-based drugs and the risk of endometrial cancer in the real-world setting.Objective: The objective of this thesis is to determine whether the use of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and dipeptidyl peptidase-4 (DPP-4) inhibitors, separately, is associated with a decreased risk of endometrial cancer. ResearchDesign and Methods: Using data from the United Kingdom Clinical Practice Research Datalink linked to the Hospital Episodes Statistics Admitted Patient Care database, Index of Multiple Deprivation and the Office for National Statistics Death Registration Data, we assembled two separate cohorts of female patients with type 2 diabetes.Using sulfonylureas (another second-to third-line drug) as an active-comparator, cohort 1 included those who were newly prescribed GLP-1 RAs or sulfonylureas and cohort 2 included those who were newly prescribed DPP-4 inhibitors or sulfonylureas from January 1, 2007 to December 31, 2020, with follow-up until March 29, 2021.Propensity score fine stratification weighted Cox proportional hazards models were used to estimate adjusted hazard ratios (HRs) and their 95% confidence Incretin-based drugs and the incidence of endometrial cancer among people with type 2 diabetes Incretin-based drugs and risk of endometrial cancer
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".