Prevention of anal human papillomavirus infection via use of a carrageenan-based gel and HPV vaccination in gay, bisexual, and other men who have sex with men
Bibliographic record
Abstract
BackgroundGay, bisexual, and other men who have sex with men (gbMSM) are disproportionately affected by human papillomavirus (HPV) infection and would benefit from preventive measures.Carrageenan, a red algae derivative, inhibits HPV infection in vitro and in vivo.However, the Lubricant Investigation in Men to Inhibit Transmission of HPV Infection (LIMIT-HPV)randomized control trial found that carrageenan use neither influenced anal HPV infection acquisition nor clearance in gbMSM.In addition, although gbMSM are eligible for HPV vaccination in Canada, there is a need for observational studies assessing its real-world impact on anal HPV infections in this at-risk population.construction.Les estimations ont été ajustées en fonction d'un score de propension permettant de prédire la positivité du VPH dans l'ensemble de l'étude, sur la base de certaines caractéristiques des participants et de l'étude. RésultatsDans le manuscrit 1, bien que la variation nette médiane de la charge virale ait été plus élevée dans le groupe traité que dans le groupe placebo, ces différences n'étaient pas significatives (VPH16 : 0,68 contre 0,18 copies/cellule, P=0,60 ; VPH18 : 18,32 contre 10,12 copies/cellule, P=0,52).Dans le manuscrit 2, 23,3 % des participants étaient vaccinés contre le VPH au début de l'étude.L'incidence des VPH ciblés par le vaccin était plus faible chez les participantes vaccinées que chez les participantes non vaccinées (n=754, rapport de risques (HR)=0,22, intervalle de confiance à 95% (IC)=0,00-0,79).La vaccination contre le VPH n'a pas été associée à l'incidence au sein d'une même espèce (n=2299, HR=0,76, IC=0,42-1,24) ou entre espèces (n=3774, HR=1,27, IC=0,88-1,83) des VPH. ConclusionsDans le manuscrit 1, l'utilisation de carraghénane n'a pas eu d'impact sur la charge virale des VPH 16 ou 18 dans l'anus, ce qui peut expliquer l'absence d'effet protecteur chez les gbHARSAH.Dans le manuscrit 2, les résultats confirment que la vaccination contre le VPH prévient les infections anales incidentes des types de VPH ciblés par le vaccin chez les gbHARSAH.v ACKNOWLEDGEMENTS Firstly, I would like to express my deepest thanks my supervisor, Dr. Eduardo Franco, for the mentorship, direction, and support he has provided over the past two years
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.004 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".