Defining the role of Epstein-Barr virus infection in multiple sclerosis : issues in exposure measurement and misclassification
Bibliographic record
Abstract
A leading hypothesis for the etiology of multiple sclerosis (MS) is that a delayed infection by Epstein-Barr Virus (EBV) generates an abnormal immune response, thereby inducing the disease. EBV is ubiquitous. While asymptomatic in children, the infection produces the clinical entity infectious mononucleosis (IM) when it is delayed until adolescence or young adulthood. Typically, case-control studies have measured exposure to EBV by serology assaying EBV antibodies or by IM self-report. The findings of these studies are not consistent.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.296 | 0.467 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.003 | 0.002 |
| Bibliometrics | 0.004 | 0.006 |
| Science and technology studies | 0.002 | 0.006 |
| Scholarly communication | 0.006 | 0.008 |
| Open science | 0.005 | 0.005 |
| Research integrity | 0.004 | 0.005 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".