Les haplogroupes mitochondriaux et le risque de cancer chez les Canadiens-français
Bibliographic record
Abstract
iv 1.8.4 Le design exprimental 40 1.9 Objectifs 45 Chapitre 2 : Matriel et Mthodes 2.1 chantillons biologiques 46 2.2 Isolement d'ADN 46 2.3 Amplification par PCR (Polytnerase Chain Reaction) 46 2.4 Transfert des produits de PCR sur membranes (Dot-Blot) 49 2.5 Marquage radioactif des sondes utilises pour les hybridations 49 2.6 Hybridation oligonuclotide allle-spcifique (ASO) 51 2.7 Digestions enzymatiques 51 2.8 Analyses statistiques 51 v 3.8 Relations entre les haplogroupes rnitochondriaux, facteurs environnementaux de risque et le risque du cancer du sein 69 3.9 Relations entre les haplogroupes rnitochondriaux, les variants allliques des gnes de rparation de l'ADN et le risque de la LLA 71 Chapitre 4 : Discussion 4.1 Considrations gnrales sur la mthode de gnotypage 78 4.1.1Le PCR multiplex 78 4.1.2Hybridation ASO 79 4.2 Les limites de l'tude 80 4.2.1 La taille des chantillons et la puissance de l'tude 80 4.2.2La structure gntique et les fausses associations 82 4.2.3Le choix des haplogroupes comme marquers tudis 84 4.3 Role du gnome mitochondrial dans le cancer 9 84 4.4 Les haplogroupes mitochondriaux et le cancer 86 4.5 Conclusion 88
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.003 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".