A novel postsynaptic role for DDC in synaptic plasticity in the adult mammalian hippocampus
Bibliographic record
Abstract
While it is well known that netrin-1 and its receptor Deleted in Colorectal Cancer (DCC) are essential for normal neural development, it remains unclear why their expression persists in the adult nervous system. We have recently demonstrated that DCC is expressed at synapses in the mature mammalian brain and that it regulates synapse function and plasticity. The precise pre- and post-synaptic functions of DCC at established synapses in the adult is not yet understood. To study the specific post-synaptic role of DCC, we generated R4ag11::Cre/DCC floxed mice in which DCC expression is selectively eliminated from CA1 hippocampal pyramidal neurons once early development has been completed, while DCC expression in the pre-synaptic neurons of the adjacent CA3 region remained intact. This conditional loss of DCC from the CA3-CA1 post-synaptic neuron resulted in abnormal dendritic spine morphology in CA1 neurons in aging mice despite maintaining overall organization and spine density. Post-synaptic DCC deficiency in these transgenic animals also resulted in deficits in spatial memory and novel place recognition tasks but failed to disrupt novel object recognition memory, suggesting that selective deletion of DCC in CA1 neurons results in disturbances in the neural circuits underlying contextual spatial memory. Together, these findings provide evidence for a critical post-synaptic role for DCC in adult mice and that DCC contributes to memory consolidation during spatial navigation.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.002 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.003 | 0.000 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".