Plasticity of the basal forebrain cholinergic system in rats with neonatal lesions of the ventral hippocampus
Bibliographic record
Abstract
Excitotoxic neonatal lesion of the ventral hippocampus (NVH) in rats has been proposed as a putative neurodevelopmental animal model of schizophrenia, with characteristic post-pubertal behavioral and neurochemical abnormalities comparable to those observed in this disease including alterations in dopaminergic (DA) neurotransmission and prefrontal cortical functions. Dysfunctions in the mesocorticolimbic DA system are believed to contribute to some of the behavioural manifestations of schizophrenia. Accumulating evidence also suggests that alterations in the activity of cortical cholinergic neurotransmission may be involved in the cognitive abnormalities seen in major neuropsychiatric disorders. These two neurotransmitter systems are functionally interlinked as the mesocorticolimbic dopaminergic system stimulates acetylcholine (ACh) release in the prefrontal cortex (PFC) mainly through the activation of D 1-like receptors. Given the involvement of the PFC and DA abnormalities in NVH lesioned animals and evidence of cholinergic abnormalities in schizophrenia, the purpose of the present thesis was to investigate the status of cholinergic system in pre and post-pubertal NVH lesioned animals, and its regulation by DA.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".