Genetic analysis of the effect of «Nramp 1» on the host and pathogen genomes in the context of chronic «Salmonella» infection
Bibliographic record
Abstract
In humans, Salmonella infections cause two major clinical diseases: salmonellosis and typhoid fever. Silent carriage of the bacteria is frequent and contributes to disease dissemination. Using a genomic approach, we have reported the identification of ten loci (Ses1-Ses10) affecting Salmonella persistence in mice. A major locus, Ses1, was validated using a congenic approach. Nramp1 remains a strong candidate gene for Ses1 although we did not detect a significant interaction between Ses1 and Nramp1-/-. We also present the creation of new double congenic strains (Ses1/Ses4 and Ses1/Ses5) that will be used to validate the inheritance model of Salmonella clearance in females. Furthermore, the influence of Nramp1 on the transcriptome of Salmonella was investigated and diverse virulence mechanisms were shown to be involved. Notably, differential phoP expression, and the resulting differential expression of PhoP-regulated genes, was observed in the presence of Nramp1. Our results confirm the importance of host-pathogen interactions in determining the outcome of infection.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".