Implementation of a lynch syndrome screening protocol on colorectal cancer patients 70 years of age and under: the initial Manitoba screening experience
Bibliographic record
Abstract
Objective: Assess the ability of a Manitoba instituted Lynch Syndrome (LS), an autosomal dominant cancer syndrome, screening protocol to identify carriers in colorectal cancer (CRC) patients as compared to literature. Methods: Three hundred sixteen CRC resection tumour cases, patient age 70, were screened for a LS profile over 18 months. Immunohistochemistry for mismatch repair deficiency (MMRD), v-raf murine sarcoma viral oncogene homolog B1 sequencing, and microsatellite instability strategies were used to determine a likelihood of LS. Genetic counselling was recommended to suspected carriers. Results: MMRD was reported in 50(16%) cases; 3(0.9%) deficient (d) MutS homolog 6 (MSH6), 8(2.5%), d MutS protein homolog 2 (MSH2)/dMSH6, 5(1.6%) d Postmeiotic segregation increased 2 (PMS2), and 34(10.7%) d MutL homolog 1 (MLH1)/dPMS2. Seventeen patients underwent germline testing; 9(2.8%) LS mutations were identified. Conclusion: A confirmed LS mutation in 2.8% of cases is a percentage comparable to literature and supports continued protocol utilization.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".