Rhamm-/- mice are defective in skin wound repair due to aberrant ERK1,2 signaling in \nfibroblast migration
Bibliographic record
Abstract
Rhamm is a hyaluronan (HA) binding protein with limited expression in normal tissues and high expression in advanced cancers.Here we show that genetic deletion of Rhamm results in defective wound granulation tissue formation/resolution. Rhamm-/-(Rh-/-) fibroblasts migrate more slowly than Wt and fail to resurface >3mm scratch wounds or invade HA-supplemented ECM gels.This defect appears to result from impaired CD44/ERK signaling that results in reduced motility speed.In Rhamm-expressing fibroblasts, Rhamm, CD44 and ERK1,2 form complexes and both Rhamm and CD44 are necessary for maximal activation of these MAP kinases and maximal motility speed.Rhamm is required to promote cell surface display of CD44 and CD44/ERK1,2 co-localization since Rh-/-fibroblasts exhibit reduced surface CD44, reduced ERK/CD44 co-association and aberrant activation/subcellular targeting of ERK1,2.Signaling defects and impaired motility are rescued by either expression of mutant active MEK1 or restoration of cell surface Rhamm (CD168).These results identify Rhamm as an essential regulator of CD44/ERK1,2 motogenic-signaling required for wound repair.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.002 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.002 | 0.001 |
| Science and technology studies | 0.001 | 0.002 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.002 | 0.003 |
| Insufficient payload (model declined to judge) | 0.013 | 0.006 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".