The role of LAR RPTPs family Receptor Protein Tyrosine Phosphatases RPTP Sigma, RPTP Delta and RPTP Lar in mouse embryonic development
Bibliographic record
Abstract
FallRPTP_Sigma, RPTP_Delta and RPTP_Lar are the three members of the LAR_RPTPs family.These members share similar structures and superposed expression patterns in different tissues.Although they are key players in different cellular functions their role in embryonic development is little known.We show that RPTP_Sigma, RPTP_Delta and RPTP_Lar are redundant in the heart and liver.Triple mutant (SDLKO) embryos show lethality starting with E12.5 and have defect in erythrocytes maturation translated by a delay in erythroblasts enucleation and persistent truncus arteriosus that leads to a failure in separation of aorta from pulmonary artery. RésuméRPTP_Sigma, RPTP_Delta et RPTP_Lar sont trois membres de la famille des LAR_RPTPs.Ces membres partagent un patron d'expression dans différents tissus et des structures similaires.Malgré le fait qu'ils sont des acteurs important de différentes fonctions cellulaires, leur rôle dans le développement embryonnaire reste mal compris.Nos résultats montrent que RPTP_Sigma, RPTP_Delta et RPTP_Lar agissent de façon redondante dans le cœur et le foie.Les embryons triple mutants (SDLKO) commencent à présenter une létalité à partir E12.5 et un défaut dans la maturation des érythrocytes se traduisant par un délai d'énucléation des érythroblastes.De plus, ces embryons montrent un truncus arteriosus persistant causant un défaut dans la séparation entre l'aorte et l'artère pulmonaire.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".