Bibliographic record
Abstract
Purpose : This study was undertaken to obtain basic data about the megakaryocyte colony formation\nof fetal liver cells by using immunocytochemical staining and ex vivo culture with growth\nfactors.\nMethods : The mononuclear cells were isolated from fetal liver and bone marrow with idiopathic\nthrombocytopenic purpura(ITP) and pancytopenia. These mononuclear cells were cultured in Mega-\nCultTM-C(Stem Cell Tech, Canada) media in the presence of growth factors and CFU-Megakaryocyte(\nCFU-Mk) colonies were counted on day 12. The expansion of CD34＋ and CD41＋ cell\nwas analyzed by flow cytometry after 5 days incubation using flask culture.\nResults : The numbers of CFU-Mk colonies of mononuclear cells obtained from fetal liver in the\n11th week gestational age were more than those in the 19th week specimens; growth factors could\nnot enhance the colony expansion in all cases. Total numbers of CFU-Mk colony of fetal liver\ncells were higher than bone marrow from ITP or pancytopenia groups. The numbers of pure or\nlarge CFU-Mk colonies of fetal liver cells were also higher than bone marrow specimens. The rate\nof CD34＋ cell expression of fetal liver was increased after flask culture and the enhancement effect\nof epression was seen only in cases which added thrombopoietin. The rate of CD41＋ cell\nexpression of fetal liver was increased after incubation, but the enhancement effect of growth factors\nwas unclear.\nConclusion : This study revealed good results about the megakaryocyte colony assay of fetal liver\nmononuclear cells using MegaCultTM-C media. This study suggests that the fetal liver could\nbe a good source of megakaryocytic progenitor cells for clinical application in hematopoietic stem\ncell transplantation. (J Korean Pediatr Soc 2002;45:247-255)
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".