Apparent bioavailability of value-added soybeans of varying isoflavone content incorporated into a bread matrix
Bibliographic record
Abstract
Food matrix and dosage affect isoflavone bioavailability, however, a bread matrix has not been studied. This study evaluated the acute and chronic bioavailability of isoflavones incorporated into breads. In a double-blind, randomized, crossover design, 15 males consumed breads of low-, intermediate-, and high-isoflavone content for 21 days each. Blood from days 1 (fasting and postprandially) and days, 2, 8, 15, and 22 (fasting) and 24-hour urine collections from days -1, 1, 7, 14, and 21 were analyzed for isoflavones. Acute results showed that serum daidzein and genistein increased dose-dependently while Tmax did not change. Chronic results showed that over time, urinary isoflavones did not change while serum isoflavones increased and that treatment effects were inconsistent for urinary and serum isoflavones and depended on isoflavone and study day. These data demonstrate that isoflavone bioavailability in a bread matrix depends on isoflavone dose and varies by specific isoflavone.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".