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Record W7036396344

Applications and dynamics of delay differential equations with threshold state-dependent delay

2025· dissertation· en· W7036396344 on OpenAlexfundno aff

Bibliographic record

VenueeScholarship@McGill (McGill) · 2025
Typedissertation
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicSpider Taxonomy and Behavior Studies
Canadian institutionsnot available
FundersNatural Sciences and Engineering Research Council of CanadaMcGill University
KeywordsDelay differential equationDynamics (music)Control theory (sociology)Stability (learning theory)Differential equationNoise (video)
DOInot available

Abstract

fetched live from OpenAlex

Delay differential equations (DDEs) with state-dependent delays defined by threshold conditions are studied.Threshold delays are implicitly determined by history states of the system over a bounded time interval.While threshold delays enhance model realism, they also pose analytical challenges.I study three different systems modeled by threshold DDEs, providing tangible strategies for tackling the threshold delays analytically and numerically to study their dynamics and bifurcations.Specifically, one approach focuses on reformulating the threshold condition through differentiation and stabilization when necessary to solve initial value problems.Another approach involves approximating the threshold delay by discretizing the distributed delay interval to solve a boundary value problem.Additionally, the effect of different delay forms, whether as a discrete constant or a discrete state-dependent delay, is examined in relation to the dynamics of the threshold delay problem.In Chapter 2 we consider an operon model with three differential equations for gene expression, accounting for time delays in DNA transcription, mRNA translation, and also models cell growth.We develop numerical techniques to solve the equations as initial value problems, and to perform numerical continuation and bifurcation detection.This is done by differentiating the threshold condition and discretizing the threshold delay.The implementations allow us to use standard software packages that are unable to handle threshold-type delays directly.Through numerical exploration of the bifurcations and dynamics of this system, we find that the inclusion of threshold delays broadens the possible operon dynamics.Namely, repressible systems may exhibit multistability and higher order bifurcation structures, and inducible systems may have stable periodic solutions.In Chapter 3 we analyze a scalar DDE modeling a transport process with a non-zero completion time, where the transport speed depends on the system's state.In contrast to the previous chapter, this model's scalar nature makes an in-depth analysis feasible.We perform systematic analytical and numerical studies of the various combinations of positive or negative feedback in the monotone nonlinear response function and the transport velocity to identify invariant objects including steady states, periodic orbits and their bifurcations.We identify rich bifurcation structures including Bautin, Bogdanov-Takens, cusp, fold, homoclinic, and Hopf bifurcations whose existence depends on the ii

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How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.504
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0010.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.013
GPT teacher head0.246
Teacher spread0.233 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractyes

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