Centrosomal protein of 55 kDa (CEP55): Expression and localization in human brain development
Bibliographic record
Abstract
Recently in Manitoba, an exceedingly rare condition was described in three children from the same family of Mennonite ancestry. All three fetuses were stillborn in the third trimester. Ultrasound examination during gestation showed oligohydramnios, small dysplastic kidneys, and hydranencephaly, a condition wherein the brain is reduced to a thin membrane. Post-mortem analysis on the infants showed that the cerebellum, brain stem, basal nuclei, and regions of the temporal and frontal lobes were hypoplastic but present. The remainder of the cerebrum was either missing or reduced to islands of tissue. Microscopic examination of the neural tissue showed multinucleated cells in all brain regions. Genetic analysis of the affected individuals showed the shared genetic mutation to be in the CEP55 gene. The CEP55 protein was previously found to be localized to the mother centriole in interphase cells and be important for regulation of cytokinesis. This is a novel mutation and the pathogenesis is not obvious. This project will use immunohistochemistry to characterize the expression patterns of the CEP55 gene in brain and kidney tissue in human and rat tissue at successive stages of fetal and postnatal development. This will be correlated with expression of the proliferation marker Ki67. The intent of these investigations is to develop a better understanding of the development of hydranencephaly and multinucleated neurons in affected individuals.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".