Decision making for bilateral mastectomy in women newly diagnosed with breast cancer
Bibliographic record
Abstract
Women diagnosed with breast cancer who carry a mutation in the genes BRCA1/2 are at an increased risk of developing cancer in the contralateral breast.Undergoing bilateral mastectomy significantly reduces the risk of developing second primary breast cancer in these women.Rapid genetic counseling and testing can provide newly affected women the opportunity to know their carrier status before undergoing any primary surgery so they can avoid an additional second surgery.Method: Forty-four women newly diagnosed with breast cancer were offered rapid genetic testing and counseling.Several psychological factors were measured at baseline and during follow-up in order to investigate the influencing factors on decision-making to undergo bilateral mastectomy in newly diagnosed women.Result: Seven out of 44 participants were identified as mutation carriers.All of the carriers underwent prophylactic surgery.Results showed no difference in cancer-related stress and general anxiety in patients opting for bilateral mastectomy compared to those who did not.All of the women were satisfied with undergoing rapid genetic counseling and testing and thought that it was offered to them at an appropriate time. Conclusion: Carrier status knowledge plays a determining role on decision-making for undergoing bilateral mastectomy.Participating in genetic testing right after diagnosis does not impose an additional distress on women.Rsum Les femmes diagnostiques d'un cancer du sein qui portent une mutation dans les gnes BRCA1/2 sont risque accru de dvelopper un cancer du sein controlatral.La mastectomie bilatrale rduit significativement le risque de cancer du sein chez ces femmes.Des tests ainsi qu'un conseil gntique rapide peuvent fournir aux femmes nouvellement affectes la possibilit de connatre leur statut de porteur avant de subir une intervention chirurgicale primaire afin qu'elles puissent viter une deuxime intervention chirurgicale supplmentaire.Mthode: Quarante-quatre femmes nouvellement diagnostiques d'un cancer du sein ont t rencontre a fin de leurs offrir un conseil gntique.Plusieurs facteurs psychologiques ont t mesurs au dpart et pendant le suivi, afin d'tudier les facteurs influenant la prise de dcision concernant l'ablation des deux seins chez les femmes nouvellement diagnostiques.Rsultat: Sept des 44 participantes ont t identifies comme porteuses d'une mutation.Toutes les porteuses ont subi la chirurgie prophylactique.Les rsultats ont montr aucune diffrence dans le stress li au cancer et l'anxit gnrale chez les patientes qui ont optes pour la mastectomie bilatrale par rapport celles qui ne l'ont pas subie.Toutes les femmes taient satisfaites de subir les tests ainsi que le conseil gntique rapide et taient de l'avis que ces derniers leurs ont t offerts en un temps opportun.Conclusion: la connaissance du status de porteur joue un rle principal dans la prise de dcision pour subir une intervention chirurgicale.Participer des tests gntiques immdiatement aprs le diagnostic n'impose pas d'inquitude supplmentaire chez ces femmes.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".