The Effects of Acute Olanzapine Exposure on Central Leptin Mediated Regulation of Energy Homeostasis and Food Intake
Bibliographic record
Abstract
Second-generation antipsychotic (SGAs) use is associated with severe metabolic side-effects which may be due to disrupted actions of leptin in the brain. We investigated the ability of olanzapine, a widely used SGA, to impair hypothalamic-leptin-mediated regulation of energy homeostasis and food intake. Healthy, male, Sprague Dawley rats received an acute intracerebroventricular (ICV) infusion of leptin or vehicle along with an acute peripheral injection of olanzapine or vehicle at the beginning of 12-h light and dark cycles. Changes in metabolic parameters were recorded using indirect calorimetry cages over 24 hours. Glucose tolerance was assessed using IPGTTs. Treatment with leptin and olanzapine, alone or in combination, reduced respiratory exchange ratio (RER) in light and dark cycles. ICV-leptin reduced dark-cycle food intake regardless of olanzapine treatment. Furthermore, treatment with olanzapine resulted in disturbed glucose tolerance. Olanzapine-induced dysglycemia appeared to be independent of hypothalamic leptin action, and ICV-leptin did not alleviate olanzapine-induced glucose intolerance.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".