A goal-directed therapeutic exercise program in paediatric posterior fossa brain tumour survivors: a case study from the Physical ACTivity in Survivorship (PACTS) randomised controlled trial
Bibliographic record
Abstract
Aims: Survivors of posterior fossa brain tumours (PFBT) experience a plethora of disease- and treatment-related complications that can persist into adulthood. Therapeutic exercise interventions have been shown to improve quality of survivorship in other paediatric cancer diagnoses. There is also evidence that goal-directed interventions are effective at improving motor activities, function, and self-care in children with other complex health conditions. There is currently no evidence on the efficacy of goal-directed therapeutic exercise in paediatric PFBT survivors. The Physical ACTivity in Survivorship (PACTS) study aims to investigate the effects of a novel, goal-directed therapeutic exercise program on cardiorespiratory fitness and physical activity-related goal attainment in PFBT. Method: PFBT survivors, aged 5-17 years, who underwent surgery at least 12 months earlier and completed radiation and/or chemotherapy at least six months prior, are being recruited. Participants are randomised into the exercise or usual care group. The exercise group receives weekly individualised, goal-directed exercise therapy delivered face-to-face for 12 weeks, alongside a home-based program (3 sessions/week). Outcomes are assessed at pre-, post-, 6- and 12-months post-intervention. Primary outcomes are cardiorespiratory fitness (Peak VO2) and physical activity-related goal attainment (Canadian Occupational Performance Measure). Secondary outcomes include cardiorespiratory endurance, high-level mobility skills, functional strength, habitual physical activity, gait, balance, quality of life, fatigue, participation, perceived motor competence and body composition. Results: Thirteen participants have been recruited (target n = 48). This case study demonstrates the application of a goal-directed exercise intervention for an 11-year-old medulloblastoma survivor who experiences ongoing motor and cognitive impairments. Self-selected participant goals included swimming, tennis, and bike riding activities. The exercise program was individualised according to the participant's goals, functional capacity, and presence of side-effects. Discussion: PACTS is the first study to investigate the efficacy of goal-directed therapeutic exercise in children with PFBT and provide evidence needed to inform clinical practice for PFBT survivors.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.007 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.002 | 0.003 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.002 | 0.001 |
| Insufficient payload (model declined to judge) | 0.006 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".