Poor Sleep as a Pathophysiological Pathway Underlying the Association between Stress Exposure and the Diurnal Cortisol Profile in Children and Adolescents
Bibliographic record
Abstract
There is increasing evidence supporting the potential contribution of poor sleep as a pathophysiological pathway underlying the association between stress exposure and disruption of the diurnal cortisol profile. Specifically, convincing evidence shows that stress exposure leads to poor sleep, which, in part, is responsible for subsequent disruption of the diurnal cortisol profile. The overarching objective of the present study was to examine whether poor sleep mediates the relation between stress exposure and the diurnal cortisol profile in children and adolescents. \nParticipants included children and adolescents aged 8-18 (N=220, M=12.62 years, 55.90% males). Participants’ salivary cortisol was sampled over two days to derive single sample (bedtime cortisol, maximum cortisol) and aggregate cortisol indices (AUCAG, AUCI, AUCTG, slopemax). Youth-report of stressful life events and daily hassles were obtained. Subjective reports of sleep duration and sleep quality were obtained by youth- and parent-report measures. \n Greater stressful life events were associated with elevated AUCAG and AUCTG. Greater daily hassles were associated with elevated maximum cortisol, AUCAG, AUCTG, and steeper slopemax. Greater stressful life events and daily hassles were associated with poorer sleep quality, which, in turn, was related to higher bedtime cortisol and AUCTG. Mediational analyses revealed that the sleep quality mediated the association between stress exposure and AUCTG. \nThe present study provided evidence for poor sleep as a potential pathophysiological pathway underlying the effects of stress exposure on the diurnal cortisol profile in children and adolescents. The current research findings have important implications and help reframe prevention efforts and public policies aimed at reducing the physiological sequelae of stress exposure. Future research should replicate current findings using objective measures of sleep to better understand specific sleep parameters that underlie the association between stress exposure and the diurnal cortisol profile.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".