Asthma and Epinephrine Administration Prior to Emergency Department Presentation for Suspected Anaphylaxis in Pediatric Patients
Bibliographic record
Abstract
Anaphylaxis is a potentially life-threatening systemic allergic reaction that involves at least two organs or systems and may result in hypotension. The mainstay of anaphylaxis treatment is epinephrine, and as such, individuals with severe allergies are recommended to carry epinephrine auto-injectors (EAIs). However, there is a substantial underutilization of EAIs for the management of anaphylaxis. One of the challenges that hinders early anaphylaxis diagnosis and management is its similarity to asthma with respect to immunopathology, clinical presentation, response to therapies, and natural history. While asthma and anaphylaxis frequently coexist and mimic each other, the exact influence of the two conditions on each other has yet to be fully explained. In the current study using data from the Cross-Canada Anaphylaxis registry (C-CARE), univariable and multivariable logistic regressions were performed to examine the association between comorbid asthma and both pre-hospital and overall epinephrine treatment. It was identified that the presence of comorbid asthma asthma was not associated with the use of pre-hospital epinephrine in the treatment of anaphylaxis and is associated with a decreased likelihood of receiving epinephrine overall. Given this finding, and the current substantial underutilization of EAIs, it is more important than ever to improve EAI prescribing practices and educate patients with allergies and relevant caregivers on prompt and safe EAI use.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".