Dissection of the Complex Genetic Architecture of Human Stature and Osteoporosis
Why is this work in the frame?
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
No Canadian affiliation. An affiliation-only frame, the usual design, would never have seen this work. It is one of the works that make the case for inverting the frame.
Full frame distilled prediction
Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
- Candidate categories
- none
- Consensus categories
- none
- Domain
- Candidate signal: noneConsensus signal: none
- Study design
- Candidate signal: ObservationalConsensus signal: Observational
- Genre
- Candidate signal: EmpiricalConsensus signal: Empirical
- Teacher disagreement score
- 0.261
- Threshold uncertainty score
- 0.785
- Validation status
machine_predicted_unvalidated·codex-gemma-dda1882f352a
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
- Teacher spread
- 0.217 · how far apart the two teachers sit on this one work
- Validation status
score_only:v0-immature-baseline· verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it
Abstract
Osteoporosis is a common complex disease mostly characterized by decreased bone mineral density (BMD). In this thesis we show that hundreds of variants affect adult height and it is the same case for many other complex traits such as bone mineral density. We have applied the novel hypothesis-free approach of Genome-wide Association Study (GWAS) to identify those loci harboring at least one variant affecting these osteoporosis-related traits.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
The record
- Venue
- RePub (Erasmus University, Rotterdam)
- Topic
- Superconducting and THz Device Technology
- Field
- Physics and Astronomy
- Canadian institutions
- not available
- Funders
- National Institute of Neurological Disorders and StrokeNational Heart, Lung, and Blood InstituteNIHR Oxford Biomedical Research CentreInstituto de Salud Carlos IIINational Institutes of HealthHjartaverndInstitut de Cardiologie de MontréalFondation Institut de Cardiologie de MontréalKulturministerietMedical Research CouncilServierSteirische WirtschaftsförderungsgesellschaftSyddansk UniversitetGöteborgs LäkaresällskapNational and Kapodistrian University of AthensBundesministerium für Verkehr, Innovation und TechnologieUmeå UniversitetSamfundet FolkhälsanVetenskapsrådetHealth Research Council of New ZealandStockholms Läns LandstingKempe FoundationHealthwayMinistry of Agriculture, Forestry and FisheriesFP7 HealthGeneralitat de CatalunyaBritish Heart FoundationBundesministerium für Bildung und ForschungKing's College LondonAustralian Cancer Research FoundationAcademy of FinlandKarolinska InstitutetDiabetestutkimussäätiöZonMwAmgen CanadaCentre for Medical Systems BiologyNovo NordiskAgency for Science, Technology and ResearchErasmus Medisch CentrumKnut och Alice Wallenbergs StiftelseErasmus Universitair Medisch Centrum RotterdamAstraZenecaEuropean CommissionNational Institute on AgingUniversity of Hong KongFolkhälsanin TutkimussäätiöNational Institute for Health and Care ResearchWellcome TrustEli Lilly CanadaCancer Research UKMarch of Dimes FoundationSvenska LäkaresällskapetNederlandse Organisatie voor Wetenschappelijk OnderzoekArthritis SocietyCedars-Sinai Medical CenterAustrian Federal Ministry of Economy, Family and YouthScottish GovernmentNational Health and Medical Research CouncilJewish General HospitalSydäntutkimussäätiöDairy Farmers of CanadaRadboud UniversiteitDonald W. Reynolds FoundationEli Lilly and CompanyCancerfondenFinska LäkaresällskapetFoundation for Cardiovascular ResearchSanofiGlaxoSmithKlineDiabetes UKJuvenile Diabetes Research Foundation InternationalProcter and GambleFondation LeducqGeelong Region Medical Research FoundationMünchner Zentrum für GesundheitswissenschaftenPfizerAmgen
- Keywords
- OsteoporosisBone mineralGenetic architectureDiseaseBone densityComplex diseaseBone diseaseGenetic association
- Has abstract in OpenAlex
- yes