Effects of dietary zinc deficiency and protein-energy malnutrition on murine splenic T lymphocyte signal transduction proteins
Bibliographic record
Abstract
Phospholipase C (PLC) and protein kinase C (PKC) are zinc metalloenzymes in the T lymphocyte signal transduction pathway. It is hypothesized that aberrations in the expression and functionality of PLC and PKC due to a lack of zinc may help explain some of the immune dysfunction observed in zinc deficiency. The objectives of the present studies were to assess the effects of zinc deficiency and malnutrition (energy, protein, or combined zinc and low protein) on animal weight, zinc status, spleen parameters, and the expression and activity of splenic T lymphocyte signal transduction proteins: PLC and PKC. An established adult murine model of zinc deficiency and protein and energy malnutrition was used to carry out these investigations. In two separate experiments, 35 female C56BL/6 adult mice were randomly assigned to one of five treatment groups [zinc deficient and 2% protein (ZLP), 2% protein (LP), zinc deficient (Z), energy restricted (ER), or control (CTL)] for four weeks. Zinc deficiency was induced in the Z and ZLP groups as assessed by lower serum and femur zinc concentrations compared to CTL (23%-65% and 78%-84% of CTL, respectively). (Abstract shortened by UMI.)
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".