The Lililwan project: neurodevelopmental outcomes and fetal alcohol spectrum disorders in remote Australian aboriginal children
Why this work is in the frame
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Bibliographic record
Abstract
Introduction and Aims: Aboriginal leaders in remote Western Australian communities, concerned about the impact of high levels of alcohol consumption in pregnancy, invited researchers to collaborate in The Lililwan Project with the objective to determine prevalence of FASD. Design and Methods: Using active ascertainment, children born in 2002/2003, living in the Fitzroy Valley in 2010/2011, were identified (n=134). In interviews, 127 (95%) consenting caregivers provided social, biomedical and antenatal data including alcohol use, with birth outcomes derived from medical records. Interdisciplinary assessments were conducted for 108 (81%) children. Prenatal alcohol exposure was objectively quantified. Conditions on the FASD spectrum (Fetal Alcohol Syndrome (FAS), partial FAS, and Neurodevelopmental Disorder – Alcohol Exposed (ND-AE)) were diagnosed using Canadian FASD Diagnostic guidelines with slight modification. Management plans were prepared for each child. Results: Alcohol was used in 55% of 127 index pregnancies. Of women who drank, 87% drank at high-risk levels and 88% drank in the first trimester. In 108 children assessed, FAS or pFAS was diagnosed in 13 (120 per 1000 (95% CI 70-196), all with confirmed prenatal alcohol exposure. Of these, 69% had microcephaly, 85% had growth deficiency, and all had facial dysmorphology and CNS impairment in 3-8 domains. Using conservative diagnostic criteria, 8 more children were diagnosed with ND-AE. Overall FA SD prevalence was 194 per 1000 (95% CI 130-280). Additional children considered at high risk for neurodevelopmental difficulties were referred for future evaluation. Discussion and Conclusions: FASD prevalence was higher than reported previously in Australia and amongst the highest worldwide. Alcohol use in pregnancy remains a major public health challenge throughout Australia, particularly in r emote communities with high rates of alcohol consumption. Aboriginal community-led initiatives for FASD prevention and FASD intervention must be supported.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it