Low-dose total body irradiation and fludarabine conditioningfor HLA class I-mismatched donor stem cell transplantation and immunologic recovery in patients with hematologic malignancies: a multicenter trial.
Bibliographic record
Abstract
HLA-mismatched grafts are a viable alternative source for patients without HLA-matched donors receiving ablative hematopoietic cell transplantation (HCT), though their use in reduced intensity or nonmyeloablative conditioning HCT has been not well established.Here we extended HCT to recipients of HLA-class I mismatched grafts to test whether nonmyeloablative conditioning can establish stable donor engraftment.Fifty-nine patients were conditioned with fludarabine 90 mg/m2 and 2 Gy total body irradiation (TBI) followed by immunosuppression with cyclosporine 5.0 mg/kg twice and mycophenolate mofetil 15 mg/kg three times daily for transplantation of granulocyte colony-stimulating factor-mobilized peripheral blood cells from related (n=5) or unrelated donors (n=54) with one antigen one allele HLA-class I mismatch or two HLA-class I allele mismatches.Sustained donor engraftment was observed in 95% of evaluable patients.The incidences of grades II to IV acute and extensive chronic graft-versus-host disease were 69% and 41%, respectively.The cumulative probability of non-relapse mortality was 47% at 2 years.Two-year overall and progression-free survivals were 29% and 28%, respectively.Nonmyeloablative conditioning with fludarabine and low-dose TBI followed by HCT using HLA-class I mismatched donors leads to successful engraftment and long-term survival; however, the high incidence of acute GVHD and NRM needs to be addressed by alternate GVHD prophylaxis regimens.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".