Riboflavin status modifies the effects of methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) polymorphisms on homocysteine
Bibliographic record
Abstract
Methylenetetrahydrofolate reductase (MTHFR)\nand methionine synthase red\nuctase (MTRR), riboflavin-\ndependent enzymes, participat\ne in homocysteine metabolism.\nReported effects of riboflavin status on the association between\nthe\nMTHFR\n677C\n[\nT polymorphism and homocysteine vary,\nand the effects of the\nMTRR\n66A\n[\nGor\nMTRR\n524C\n[\nTpoly-\nmorphisms on homocysteine are unclear. We tested the\nhypothesis that the effects of the\nMTHFR\n677C\n[\nT,\nMTRR\n66A\n[\nGand\nMTRR\n524C\n[\nT polymorphisms on fasting plasma\ntotal homocysteine (tHcy) depen\nd on riboflavin status (eryth-\nrocyte glutathionine reductase\nactivation coefficient, optimum:\n\n1.2; marginally deficient: 1.2–1.4; deficient:\nC\n1.4) in 771\nadults aged 18–75 years.\nMTHFR\n677T allele carriers with\nmiddle or low tertile plasma folate (\n\n14.7 nmol/L) had 8.2 %\nhigher tHcy compared to the 677CC genotype (\np\n\n0.01). This\neffect was eliminated when riboflavin status was optimal (\np\nfor\ninteraction: 0.048). In the\nlowest cobalamin quartile\n(\nB\n273 pmol/L), riboflavin status modifies the relationship\nbetween the\nMTRR\n66 A\n[\nG polymorphism and tHcy (\np\nfor\ninteraction: 0.034). tHcy was 6.6 % higher in\nMTRR\n66G allele\ncarriers compared to the 66AA\ngenotype with marginally\ndeficient or optimal riboflavin status, but there was no differ-\nence when riboflavin status was deficient (\np\nfor interaction:\n0.059). tHcy was 13.7 % higher in\nMTRR\n524T allele carriers\ncompared to the 524CC genoty\npe when cobalamin status was\nlow (\np\n\n0.01), but no difference was observed when we\nstratified by riboflavin status. The effect of the\nMTHFR\n677C\n[\nT polymorphism on tHcy depends on riboflavin status,\nthat of the\nMTRR\n66A\n[\nG polymorphism on cobalamin and\nriboflavin status and that of the\nMTRR\n524C\n[\nT polymorphism\non cobalamin status
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".