Vankomisine dirençli enterokokların moleküler epidemiyolojisi ve antibiyotik duyarlılıklarının irdelenmesi
Bibliographic record
Abstract
Vancomycin-resistant Enterococci (VRE) are important nosocomial infection agents which have become widespread in recent years. The legal obligation to establish hospital infection control committees and increase in monitoring studies in Turkey has generalized VRE notifications. The treatment options for VRE-induced infections are limited. This study was conducted to identify the molecular epidemiology of the VRE sources found in the study hospital, and to determine the resistance of these strains to various antibiotics. The study was carried out on strains isolated in the microbiology laboratory of Şahinbey Research and Application Hospital, University of Gaziantep. Strains were identified at species level via conventional methods and a fully automated Vitek 2 (Biomerieux, France) identification system. Vancomycin sensitivity was tested via disc diffusion method and E-test (AB Biodisc) strips. Resistance genes of these strains were analyzed via PCR method using GeneOhm VanR (Becton Dickinson, Canada) moleculer tests. In vitro antibacterial efficiency of linezolid, dalfopristin, gentamicin, streptomycin and imipenem was analyzed via the disc diffusion method. All 81 strains included in the study were identified as Enterococcus faecium. VanA gene-type resistance was recorded in 76 (93.8%); vanB gene-type resistance in 2 (2.5%); and nonA-nonB type resistance in 3 (3.7%) of the study strains. No resistance was detected in any of the linezolid and dalfopristine strains. 75 VRE strains (92.6%) were found to be resistant to gentamicin, 28 strains (34.6%) to streptomycin and 79 strains (97.5%) to imipenem. Linezolid and dalfopristin were found to have complete in vitro efficiency against VRE strains, while these strains were found to be highly resistant to other antibiotics tested in the scope of the study. Since treatment of VRE-induced infections is relatively difficult, it is suggested that careful implementation of preventive measures is of great importance to patients in the fight against this agent.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".