Cannabinoid receptors in animal models of acute, tonic and chronic pain
Bibliographic record
Abstract
The aim of the work presented here is to evaluate the effects of cannabinoids in three animal models of pain: acute, tonic and chronic. The tail flick test (acute pain) was used to test the effect of the cannabinoid agonist, WIN 55,212--2, on tail withdrawal latency from a noxious radiant heat source. It was also tested on the allodynia induced by either endogenous release or exogenous administration of substance P. WIN 55,212--2 was antinociceptive in this test, and blocked the substance P-induced allodynia, suggesting a post-synaptic site of action. The formalin test (tonic pain) was used to test the effects of the endogenous cannabinoid agonist, anandamide and the cannabinoid receptor antagonist AM 281. Anandamide was antinociceptive (with a short duration of action), and AM 281 was pronociceptive. When administered concomitantly, AM 281 blocked the effects of anandamide. When given alone and in the absence of a noxious stimulus, AM 281 was without effect. (Abstract shortened by UMI.)
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.007 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".