The effects of the SCCmec element and colony spreading on the virulence of methicillin resistant Staphylococcus aureus in a nematode model
Bibliographic record
Abstract
Methicillin resistant Staphylococcus aureus presents clinical challenges. The ability of S. aureus to cause human disease is correlated with the nematocidal activity of that isolate. This thesis investigates the relationship between SCCmec type, colony spreading, and the presence of the fudoh/psm-mec region of MRSA isolates to their ability to kill Caenorhabditis elegans. PCR was used to test for the fudoh/psm-mec region in 420 CMRSA2 isolates and 155 CMRSA1 isolates. Spread plate assays were performed on 149 CMRSA2 isolates to determine correlation between SCCmec type and colony spreading. Fudoh/psm-mec was correlated with the infection/colonization status of a patient. SCCmec type IV was correlated with increased spreading ability. SCCmec type, PFGE type, spa type, and colony spreading ability of 40 MRSA isolates were determined; these isolates were characterized using a nematode killing assay. It was found that the colony spreading ability of an isolate correlated with the nematocidal ability of that isolate.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".