HALLAZGOS CLÍNICOS Y HEMATOLÓGICOS EN CANINOS INMUNOESTIMULADOS SOMETIDOS A CONDICIONES DE CAMPO EN UNA ZONA ENDEMICA DE EHRLICHIOSIS MONOCITICA CANINA DEL ESTADO LARA, VENEZUELA
Bibliographic record
Abstract
En el presente trabajo se reportan los hallazgos clínicos y hematológicos en caninos tratados con un\ninmunoestimulante basado en células inactivadas de Propionibacterium granulosum y Lipopolisacáridos\nde Escherichia coli (Pg-LPS) en un área endémica de Ehrlichiosis monocítica canina (EMC). Se evaluaron\ndiez caninos en el grupo control (GC) y diez caninos en el grupo experimental (GE). Se les realizó la\ndetección de E. canis mediante la técnica de PCR específica, al inicio y al final del estudio, así como un\nexamen clínico completo y una determinación de parámetros hematológicos semanales. Se observó que\n5 (50%) caninos del GE y 6 (60%) del GC ingresaron al estudio infectados por E. canis. Luego de nueve\nsemanas de exposición, el número de infectados del GE permaneció constante mientras que elGC aumentó.\nEl GE desarrolló linfoadenomegalia como consecuencia de la infección, la cual fue descendiendo de 80 a\n30 %, además el 90% presentó fiebre no recurrente y se observó trombocitopenia leve (100.000-170.000\nx mm3) por 4 semanas. Por su parte, el GC aumentó la linfoadenomegalia de 20 a 80% y un 80%\ndesarrollaron fiebre recurrente, además de trombocitopenia severa a las 2 semanas (< 100.000 x mm3) y\nleve en la cuarta semana. Estos hallazgos muestran que los caninos inmunoestimulados con Pg-LPS\npresentaron una evolución positiva a la infección al no aumentar el número de infectados y presentar\nmejoría en el cuadro clínico y hematológico, y evitar en algunos casos la infección con E. canis o eliminar\nel microorganismo de la sangre en aquellos que resultaron positivos a la prueba de PCR específica al\ninicio del estudio y de mejorar el pronóstico de la EMC. \nPALABRAS CLAVES: Ehrlichiosis, inmunoestimulante, hallazgos, evolución \n\nABSTRACT \nIn this paper we report the clinical and hematological findings in dogs treated with an immunostimulatory cell\nbased inactivated Propionibacterium granulosum and Escherichia coli lipopolysaccharide (Pg-LPS) in an\nendemic area of canine monocytic ehrlichiosis (CME). Ten dogs were evaluated in the control group (CG)\nand ten dogs in the experimental group (EG). Was performed to detect E. canis by specific PCR technique at\nthe beginning and end of the study and a thorough clinical examination and determination of weekly\nhematological parameters. It was found that 5 (50%) dogs of GE and 6 (60%) entered the study GC infected\nE. canis. After nine weeks of exposure, the number of cases of GE remained constant while the GC increased.\nThe lymphoadenomegaly GE developed as a result of infection, which was descending from 80 to 30%, and\n90% showed no fever was observed recurrent mild thrombocytopenia (100,000 to 170,000 x mm3) for 4\nweeks. In turn, the increased GC lymphoadenomegaly of 20 to 80% and 80% developed recurrent fever,\nsevere thrombocytopenia addition at 2 weeks (<100,000 x mm3) and fourth weeks mild. These findings\nshow that the canines immunostimulated with Pg-LPS showed a positive development to infection by not\nincreasing the number of infected and have an improvement in clinical and hematological, suggesting\nstimulated the immune system of the canines of GE, to avoid in some cases the infection with E. canis or\neliminating the organism from the blood of those who tested positive for specific PCR test at baseline and\nimprove the prognosis of the EMC. \nKEYWORDS: Ehrlichiosis, immunostimulant, findings, trends.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".