Morphological and functional remodelling of the neuromuscular junction by skeletal muscle PGC-1 alpha
Bibliographic record
Abstract
The neuromuscular junction (NMJ) exhibits high morphological and functional plasticity. In \nthe mature muscle, the relative levels of physical activity are the major determinants of NMJ \nfunction. Classically, motor neuron-mediated activation patterns of skeletal muscle have been \nthought of as the major drivers of NMJ plasticity and the ensuing fibre-type determination in \nmuscle. Here we use muscle-specific transgenic animals for the peroxisome proliferatoractivated receptor g co-activator 1a (PGC-1a) as a genetic model for trained mice to elucidate \nthe contribution of skeletal muscle to activity-induced adaptation of the NMJ. We find that \nmuscle-specific expression of PGC-1a promotes a remodelling of the NMJ, even in the \nabsence of increased physical activity. Importantly, these plastic changes are not restricted to \npost-synaptic structures, but extended to modulation of presynaptic cell morphology and \nfunction. Therefore, our data indicate that skeletal muscle significantly contributes to the \nadaptation of the NMJ subsequent to physical activity
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".