Reduced bone density accrual among peripubertal boys with HIV in Zimbabwe
Bibliographic record
Abstract
Objective: To investigate bone density accrual over 1 year among peripubertal children with HIV (CWH) compared to children without infection (CWOH); and risk factors associated with bone density accrual among CWH. Design: A prospective cohort study in urban Zimbabwe. Methods: CWH on antiretroviral therapy aged 8–16 years, and CWOH, frequency-matched by age were recruited in Zimbabwe. Z-scores for height-adjusted total-body less-head bone mineral content for lean mass (TBLH-BMCLBM) and size-adjusted lumbar spine bone mineral apparent density (LS-BMAD) were calculated from dual X-ray absorptiometry (DXA) scan measurements. Linear regression compared bone density accrual by HIV status. Results: Of 609 participants, 492 (80.7%) completed a follow-up visit (50.2% boys, 49.6% CWH). Mean baseline age was 12.5 years. More girl CWH than CWOH were in Tanner stages I/II at baseline. Bone density accrual (Δ) adjusted for age, Tanner stage and baseline DXA Z-score was less in boy CWH than boy CWOH {adjusted mean (95% confidence interval (CI)] ΔLS-BMAD Z-score −0.14 (−0.25 to −0.02) vs. 0.01 (−0.09 to 0.12), P = 0.020, and ΔTBLH-BMCLBMZ-score −0.19 (−0.33 to −0.04) vs. 0.07 (−0.07 to 0.20), P = 0.015}, but similar in girls with and without HIV [ΔLS-BMAD Z-score 0.05 (−0.07 to 0.17) vs. −0.01 (−0.09 to 0.07), P = 0.416, and ΔTBLH-BMCLBMZ-score 0.08 (−0.07 to 0.22) vs. −0.03 (−0.12 to 0.07), P = 0.295]. Viral load greater than 1000 copies/ml and tenofovir disoproxil fumarate use were associated with less gain in LS-BMAD Z-score among boys, whereas Tanner stage IV and V were associated with greater gains in LS-BMAD and TBLH-BMCLBMZ-scores among CWH. Conclusion: Among boys only, CWH had impaired bone accrual, associated with high viral load and tenofovir use. Bone density gains were greater in later puberty among CWH suggesting potential to correct deficits.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.001 | 0.002 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".