Understanding the role of child social determinants of health and inflammatory bowel disease: A Scoping Review Study Protocol
Bibliographic record
Abstract
This research project aims to conduct a scoping review to explore the relationship between childhood social determinants of health (CSDoH) and the development of inflammatory bowel disease (IBD), a chronic autoimmune condition that includes Crohn’s disease and ulcerative colitis. While IBD affects 7–10 million individuals globally and is increasingly common in children under the age of 18, particularly in Canada [1], the role of early-life social factors in influencing disease onset remains poorly understood. The study is grounded in the growing recognition that non-medical social factors such as income, housing, education, and family environment can profoundly affect health outcomes [2]. The central hypothesis is that certain adverse CSDoH may be associated with an increased risk of developing IBD during childhood or adolescence. This scoping review will follow the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocols - Extension for Scoping Reviews) and the methodological framework by Arksey and O’Malley [3]. Three major databases, PubMed, SCOPUS, and PsychInfo, will be systematically searched using MeSH and keyword terms related to IBD and each of the 13 CSDoH of interest. These childhood SDoH include: low-income household; rural or remote location; family received income assistance; parent involved in the criminal justice system; parent did not graduate high school; lived in social housing; parent immigrated from another country; family with high residential mobility (i.e., moved frequently); child of a teen mother; mental disorder as a child; mother with a mental disorder; mother with a physical disorder; and being placed in the care of another adult. Studies published in English between 2000 and 2024 will be identified through searches of PubMed, SCOPUS and PsychInfo using MeSH and keyword terms for inflammatory bowel disease (IBD) and 13 predefined childhood social determinants of health (CSDoH). All study types will be considered if they examine IBD in relation to at least one CSDoH. Two reviewers will independently screen titles, abstracts, and full texts, with a third reviewer resolving any disagreements. Data will be charted using Covidence and Excel, and findings will be summarized narratively and in tables, following PRISMA guidelines [4]. The review will identify key themes, research gaps, and inform socially-informed IBD prevention strategies. We will examine the evidence base to understand more about the role of adverse childhood social determinants of health and development of IBD. Our approach will allow us to understand the current state of the literature in this area as well as help identify gaps that can be addressed by future investigation in this area. The results may also help us identify possible points of intervention for the prevention of inflammatory bowel disease in high-risk groups. This project will also inform an administrative data-based project on CSDoH and IBD among Manitobans. Citations: 1. Carroll MW, Kuenzig ME, Mack DR, et al. The Impact of Inflammatory Bowel Disease in Canada 2018: Children and Adolescents with IBD. J Can Assoc Gastroenterol. 2019;2(Suppl 1):S49-S67. doi:10.1093/jcag/gwy056 2. Braveman P, Gottlieb L. The social determinants of health: It’s time to consider the causes of the causes. Public Health Rep. 2014;129(Suppl 2):19-31. doi:10.1177/00333549141291S206 3. Arksey H, O’Malley L. Scoping studies: Towards a methodological framework. Int J Soc Res Methodol. 2005;8(1):19-32. doi:10.1080/1364557032000119616 4. Tricco AC, Lillie E, Zarin W, et al. PRISMA Extension for Scoping Reviews (PRISMA-ScR): Checklist and Explanation. Ann Intern Med. 2018;169(7):467-473. doi:10.7326/M18-0850
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.004 | 0.003 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".