265: Variation in patient selection and outcomes of ECMO bridge to lung transplant across high and low volume centers: An analysis of the ELSO database
Bibliographic record
Abstract
Background: ICU-acquired weakness (ICUAW) is a frequent complication among critically ill patients supported with ECMO and may impair functional recovery during hospitalization. Emerging evidence suggests female patients may be at greater risk due to physiologic differences or disparities in rehabilitation engagement. However, sex-specific differences in inpatient functional outcomes among ECMO patients remain underexplored. This study aimed to evaluate sex-based differences in inpatient mobility and functional outcomes among adult ECMO patients. Methods: Single-center retrospective study of adults (≥18 years) on ECMO in 2023. Exclusions: age <18, pregnancy, incarceration, >48h ECMO at outside hospital, repeated ECMO run, or missing Activity Measure for Post-Acute Care (AMPAC) assessment. Results: Among 83 ECMO patients (63% male), females reached early mobility milestones more quickly than males. Median time to sitting at edge of bed was 6.5 days for females versus 11.5 days for males (p=0.008). Time to standing was 7 days for females and 13 days for males (p=0.017). However, there was no significant difference in ambulation timing (p=0.198). Females initiated PT later than males (p=0.031). ICUAW was nearly universal (Female: 96.8%, Male: 100%). Patients with ≥9 days of sedation experienced significantly delayed ambulation (p=0.000015). Males had a higher rate of non-favorable discharge destinations (hospice/morgue). Conclusion: Females reached mobility milestones quicker than males despite delayed PT initiation. ICUAW was nearly universal. Sedation ≥9 days was strongly associated with delayed ambulation. These findings highlight the need for sex-conscious rehabilitation planning and careful sedation management to optimize inpatient recovery following ECMO.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".