OF THE CANADIAN DERMATOLOGY STUDY GROUP ON HEALTH-RELATED QUALITY OF LIFE IN PRIMARY AXILLARY
Bibliographic record
Abstract
BACKGROUND. Patients with primary axillary hyperhidrosis expe-rience substantial functional impairment and reduced health-related quality of life (HRQOL). Few studies have comprehen-sively evaluated the effects of botulinum toxin type A (BoNT-A) on these symptoms. OBJECTIVE. To prospectively assess the effects of BoNT-A on functional impairment associated with primary axillary hyper-hidrosis. METHODS. Patients treated with BoNT-A 50 U per axilla at base-line were assessed 4 and 12 weeks later. Outcome measures included functional impairment as assessed by the Hyperhidrosis Disease Severity Scale and the Hyperhidrosis Impact Question-naire and dermatology-specific HRQOL as assessed by the Der-matology Life Quality Index. RESULTS. At weeks 4 and 12 after BoNT-A treatment, 85 % and 90 % of patients achieved the a priori definition of treatment responder. Patients reported less occupational and emotional impairment, spent less time managing their hyperhidrosis, and had fewer difficulties in social situations. Adverse events were uncommon (5.5%), were mild, and did not require treatment. At study end, 53 % of patients reported no dermatology-specific HRQOL impairment and 90 % were satisfied with treatment. CONCLUSIONS. Significant, meaningful, rapid, and durable reduc-tions in disease severity and functional impairment, as well as improvements in HRQOL, were seen following BoNT-A treat-ment. BoNT-A was safe and well tolerated, producing high lev-els of patient satisfaction.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".