The effect of recombinant tissue plasminogen activator on cognitive functions of patients with first ischemic stroke
Bibliographic record
Abstract
Abstract Background Stroke is associated with significant comorbidities & cognitive impairment affects more than 50% of patients with ischemic stroke. Reperfusion therapy is considered the most effective therapy & has a significant positive impact on function & quality of life of stroke patients presented within 4.5 h from onset of symptoms. Aim of current study is to assess the cognitive functions among patients with first ischemic stroke who received recombinant tissue Plasminogen activator (t-PA) (r-TPA) in comparison with patients with first ischaemic stroke who didn’t receive rTPA. Patients & methods A comparative cross-sectional study was conducted among 2 groups of patients with first ischaemic stroke. Group A: included 51 patients who were presented before 4.5 h of onset of symptoms & received rTPA while group B included 51 patients who were not eligible to receive rTPA. Patients were evaluated for cognitive impairment using the Mini-Mental State Examination, Montreal Cognitive Assessment & Wisconsin Card sorting Test after 3 months of stroke for both groups. Results Three months after the intervention, Group A showed significantly better cognitive performance than Group B. Group A scored higher on the MMSE ( p < 0.001), particularly in orientation, registration, attention, calculation, & language ( p < 0.05), though both groups performed similarly in recall. On the MoCA, Group A also had higher total scores ( p < 0.001), especially in visuospatial skills, memory, attention, & executive function ( p < 0.05), with no significant difference in orientation & language. In the WCST, Group A made fewer errors & had better conceptual responses, while Group B showed more perseverative responses & errors & non-perseverative errors ( p < 0.001). In addition, MOCA, MMSE & WCST scores 3 months after intervention had significant moderate negative correlation with NIHSS scores. Conclusion Cognitive impairment is less reported among stroke patients managed with r-TPA suggesting a protective effect for r-TPA on cognitive function.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".