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Record W7103165661 · doi:10.1080/14796708.2025.2568377

Plain language summary of publication: expert consensus on the early use of long-acting injectable antipsychotics in people with bipolar I disorder

2025· article· en· W7103165661 on OpenAlexafffund

Bibliographic record

VenueFuture Neurology · 2025
Typearticle
Languageen
FieldMedicine
TopicBipolar Disorder and Treatment
Canadian institutionsUniversity of TorontoUniversity of British Columbia
FundersCanadian Institutes of Health ResearchNational Institutes of HealthOtsuka PharmaceuticalIdorsia PharmaceuticalsSunovionH. Lundbeck A/SCenters for Disease Control and PreventionBausch HealthEisaiNational Natural Science Foundation of ChinaNeurocrine BiosciencesEpilepsy SocietyUniversity of OxfordPurdue UniversityNovo NordiskTeva Pharmaceutical IndustriesGedeon RichterPfizerBiogenSanofiOtsuka Pharmaceutical Development and CommercializationJohns Hopkins UniversityAstraZenecaEli Lilly and CompanyBristol-Myers Squibb
KeywordsBipolar disorderMoodPlain languageTreatment of bipolar disorderMental healthDepression (economics)Health care

Abstract

fetched live from OpenAlex

Plain Language SummaryWhat is this summary about?This summary highlights key insights from expert psychiatrists on the early use of long-acting injectable (LAI) antipsychotics for treating people with bipolar I disorder.What were the results?LAI antipsychotics are usually reserved as a ‘last resort’ treatment in people with bipolar I disorder, even though evidence supports their early use. Barriers to earlier use of LAIs include access issues and views that healthcare providers and people with bipolar I disorder have about this type of medication. If the treatment plan of people with bipolar I disorder includes antipsychotics, experts recommend using LAIs as early as possible to help improve long-term outcomes, as part of a shared decision-making approach that involves healthcare providers, people with bipolar I disorder, and their caregivers.What do the results mean?The recommendations offer ways to support informed treatment decisions and improve the care of people with bipolar I disorder.How to say (download PDF and double click sound icon to play sound)…Antipsychotic: an-tie-sy-COT-ickAripiprazole: a-ri-PIP-ruh-zolBipolar disorder: by-POL-luh dis-or-derMania: MAY-nee-uhPsychosis: sy-KOH-sisLong-acting injectable (LAI): A form of medication that is given via a needle into the body and is released in the body over a long period of time.Antipsychotics: Medicines that help manage symptoms of mental health conditions like bipolar disorder.Bipolar I disorder: A long-term mental health condition where individuals have intense mood swings, which can range from depression to mania.This is an abstract of the Plain Language Summary of Publication article.View the full Plain Language Summary PDF of this article to read the full-textLink to original article here

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.022
Threshold uncertainty score0.304

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.012
GPT teacher head0.257
Teacher spread0.245 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes2
Has abstractyes

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