Bibliographic record
Abstract
目的 探讨血清去磷酸化未羧化的基质Gla蛋白（dephosphorylated uncarboxylated matrix Gla protein,dp-ucMGP）及血清骨形态发生蛋白2(bone morphogenetic protein-2,BMP-2)与维持性血液透析（maintenance hemodialysis,MHD）患者认知功能障碍（cognitive impairment,CI）的关系。方法 选择2021年6月1日至2023年4月30日在石河子大学第一附属医院及石河子市人民医院行MHD的患者254例。收集患者一般及实验室资料，采用中文版蒙特利尔认知评估量表（Chinese version of montreal cognitive assessment,C-MoCA）对所有患者进行认知功能评估，并采用酶联免疫吸附试验检测患者血清dp-ucMGP及BMP-2水平。结果 纳入的254例患者中，C-MoCA量表筛选出CI患者192例。CI组患者年龄[57.0(50.0,67.7)岁比48.0(35.0,54.0)岁]、收缩压[137(129,148)mmHg比134(125,142)mmHg](1 mmHg=0.133 kPa)、女性比例（40.1%比22.6%）、高血压比例（76.6%比45.2%）、受教育年限（≤6年：30.7%比4.8%;>6，≤9年：41.2%比27.4%）、血清dp-ucMGP[9.05(7.81,10.71)μg/L比5.95(4.43,7.21)μg/L]及BMP-2水平[114.72(101.07,140.44)ng/L比89.65(74.17,101.74)ng/L]高于NCI组患者（P<0.05），而受教育年限（>9,<13年：20.3%比45.2%；≥13年：7.8%比22.6%）低于NCI组患者（P<0.05）。二元Logistic回归分析显示年龄、收缩压、血清dp-ucMGP及BMP-2水平与MHD患者CI相关（P<0.05）。Spearman相关分析显示MHD患者血清dp-ucMGP水平与C-MoCA评分、视空间与执行功能、注意、语言、抽象、延迟回忆、定向呈负相关（P<0.05）。血清BMP-2水平与C-MoCA评分、视空间与执行功能、命名、注意、语言、抽象及延迟回忆呈负相关（P<0.05）。结论 血清dp-ucMGP及BMP-2是MHD患者发生CI的危险因素，并且其水平可能与CI严重程度有关。
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.005 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.002 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.002 | 0.002 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.007 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".