One-stop automated diagnostic system for active sacroiliitis in three-dimensional magnetic resonance images using artificial intelligent models: a retrospective study
Bibliographic record
Abstract
Axial spondyloarthritis (axSpA) can potentially progress to ankylosing spondylitis, and diagnostic delay may lead to irreversible structural damage. Although sacroiliac joint magnetic resonance imaging (MRI) can detect bone marrow edema (BME) for early diagnosis, the complex etiologies and reliance on expert interpretation impede efficient identification in chronic low back pain populations. Therefore, we developed an artificial intelligence system that integrates MRI analysis and automated report generation to facilitate the detection of active sacroiliitis detection and BME quantification. This retrospective study analyzed 691 patients (540 with axSpA and 151 with non-spondyloarthritis) from the Chinese People’s Liberation Army General Hospital (2011–2023). Data were split into training and testing cohorts (4:1 ratio), with five-fold cross-validation applied to the training set. The system comprises four modules: (1) image preprocessing (intensity normalization); (2) coarse-to-fine 3D U-Net-based quadrant segmentation; (3) ResNet18-driven edema recognition (depth/intensity classification); and (4) diagnostic report generation using the QWEN large language model. Among 691 patients (335 active sacroiliitis-positive, 356 negative), the AI system achieved Spondyloarthritis Research Consortium of Canada (SPARCC) scores of (15.12±10.73) vs . (0.88±1.13) in positive versus negative groups. The quadrant segmentation module achieved DICE similarity coefficients above 0.7 on the training, validation and testing datasets. The edema inflammation, depth and intensity classifier exhibited good performance on the testing dataset, with balanced accuracies of 77.54 %, 76.27 % and 80.91 %, and area under the curve values of 0.85, 0.87 and 0.92, respectively. The intraclass correlation coefficient between SPARCC scores by our system and those by rheumatologists is 0.84 on the testing dataset. At patient-level, our system achieved 90.81 % sensitivity for diagnosis of active sacroiliitis on the testing dataset. The developed automated system enhances axSpA diagnostic efficiency by automating the identification of active sacroiliitis and enabling quantitative assessment of BME.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".