S4539 Cutting Through Challenges: Endoscopic Submucosal Dissection for Esophageal Adenocarcinoma Amidst Variceal Vulnerability
Bibliographic record
Abstract
Introduction: Endoscopic submucosal dissection (ESD) offers a curative, organ-preserving approach for early esophageal adenocarcinoma (EAC), particularly in patients who are poor surgical candidates. However, the presence of esophageal varices, commonly due to portal hypertension, poses significant hemorrhagic risk, often limiting the use of standard endoscopic therapies. Also, current surveillance guidelines typically reserve intervention for Barrett’s esophagus (BE) segments ≥1 cm unless additional risk factors are present. We present a rare case of EAC arising in nodular short-segment BE in a cirrhotic patient with esophageal varices, successfully managed with ESD. Case Description/Methods: A 67-year-old man with a history of cirrhosis underwent EGD for surveillance. A nodular lesion at the GE junction was noted within a 1 cm segment of BE, along with grade 2 esophageal varices. Biopsies revealed villous architecture with high-grade dysplasia and intramucosal adenocarcinoma. PET imaging showed no metastasis. Due to cirrhosis and varices, he was deemed high-risk for surgery and referred for endoscopy. ESD was performed with thermal marking and submucosal lifting using methylene blue solution. A 3 × 5 cm en bloc resection was achieved, encompassing the lower esophagus and gastric cardia. Visible vessels were coagulated prophylactically. There were no immediate or delayed bleeding complications. Pathology confirmed moderately differentiated adenocarcinoma with submucosal invasion (5 mm), arising in BE with high-grade dysplasia. All margins were negative. At 6-month follow-up, EGD showed residual varices but no recurrent neoplasia. Biopsies revealed only mild chronic inflammation. Discussion: This case supports the feasibility of ESD in patients with early EAC and concurrent varices when surgical resection is contraindicated. While varices are generally considered a relative contraindication due to bleeding risk, careful planning and hemostatic technique can mitigate complications. Watanabe et al. (Endosc Int Open, 2020) demonstrated the technical safety of ESD in similar contexts and our case adds to this emerging evidence. Additionally, while short-segment BE is typically considered low risk, nodularity or dysplasia warrants close surveillance. Barrie et al. (Surg Endosc, 2021) reported that EAC can arise in very short segments of BE, challenging traditional models. This case shows the need for individualized assessment and highlights ESD as a viable option in complex clinical settings.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.002 | 0.001 |
| Insufficient payload (model declined to judge) | 0.007 | 0.004 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".