(080) Impact of the Optilume BPH Catheter System on Sexual Function and Voiding Outcomes: A Systematic Review
Bibliographic record
Abstract
Abstract Introduction Benign Prostatic Obstruction (BPO) is increasingly prevalent and a common cause of lower urinary tract symptoms (LUTS), significantly impacting quality of life. While traditional medical and surgical treatments are effective in relieving symptoms, they often carry a risk of sexual dysfunction. This has led to the development of minimally invasive surgical therapies (MISTs) aimed at preserving sexual function while improving urinary outcomes. The Optilume BPH Catheter System is a novel MIST that combines mechanical dilation of the prostatic urethra with localized delivery of paclitaxel to treat LUTS secondary to BPO. This systematic review evaluates current evidence on its impact, focusing primarily on sexual function and secondarily on voiding parameters. Objective To systematically assess available evidence on Optilume BPH Catheter System and its outcomes on sexual function and voiding parameters. Methods This systematic review was conducted in accordance with PRISMA guidelines. A comprehensive search Google scholar, Web of science, PubMed, Scopus and ClinicalTrials.gov was performed. Studies were screened and selected using Covidence, and data were extracted into Microsoft Excel. Outcomes of interest included sexual function measures such IIEF-5, MSHQ-Ejaculatory Function (EjF), and Ejaculatory Bother (EjB); along with validated instruments for LUTS such as the International Prostate Symptom Score (IPSS). Risk of bias was assessed using the Cochrane Risk of Bias 2.0 tool (ROB-2) for randomized studies and the Newcastle Ottawa Scale (NOS) for observational studies. Descriptive statistics were generated using Excel and SPSS v29. Results Of 141 screened records, two studies met inclusion criteria: one randomized controlled trial and one prospective single-arm study, encompassing a total of 180 patients treated with Optilume. Follow-up data were collected at 6, 12, and 24 months post-treatment. Sexual function outcomes showed a mean improvement in IIEF-5 scores of +2.86 (p < 0.05) at 6 months, +2.76 (p < 0.05) at 12 months, and +2.9 (p > 0.05) at 24 months. Changes in MSHQ-EjF and EjB scores were minimal and not statistically significant across all time points (all p > 0.05). This shows that sexual function is effectively preserved in the post-operative period. Voiding outcomes demonstrated consistent and significant improvement, with IPSS decreasing by an average of 13.2 points (57%) at 24 months. Conclusions Early clinical evidence suggests that the Optilume BPH Catheter System provides substantial and sustained improvement in urinary symptoms while preserving sexual function. These findings position Optilume as a promising addition to the MIST landscape. However, given the limited number of studies and relatively short follow-up, further large-scale, long-term investigations are necessary to validate its efficacy and safety across broader patient populations. Disclosure No
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.008 | 0.033 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.007 | 0.008 |
| Bibliometrics | 0.007 | 0.008 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.003 | 0.002 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.002 | 0.001 |
| Insufficient payload (model declined to judge) | 0.008 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".