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Record W7112330988

Tau PET positivity in individuals with and without cognitive impairment varies with age, amyloid-β status, APOE genotype and sex

2024· article· en· W7112330988 on OpenAlexfundno aff

Bibliographic record

VenueJuSER (Forschungszentrum Jülich) · 2024
Typearticle
Languageen
FieldMedicine
TopicDementia and Cognitive Impairment Research
Canadian institutionsnot available
FundersNational Institute on AgingInstitut de Recherches ServierNational Health and Medical Research CouncilCanadian Institutes of Health ResearchIrving Medical Center, Columbia UniversityAvid RadiopharmaceuticalsParkinsonfondenEMD SeronoAstraZenecaEuropean CommissionFondation pour la Recherche sur AlzheimerGenentechNational Institutes of HealthArizona Biomedical Research CommissionKnut och Alice Wallenbergs StiftelseIXICOH. Lundbeck A/SSkånes universitetssjukhusAlzheimer's Disease Neuroimaging InitiativeStichting DioraphteKonung Gustaf V:s och Drottning Victorias FrimurarestiftelseNovo NordiskServierVetenskapsrådetUniversity of Southern CaliforniaEisaiAustralian GovernmentLunds UniversitetAlzheimerfondenGovernment of CanadaZonMwU.S. Department of DefenseCommonwealth Scientific and Industrial Research OrganisationAlzheimer SocietyAlzheimer NederlandCerveau TechnologiesPfizer CanadaFondation Brain CanadaGHR FoundationProthenaAlzheimer's AssociationArizona Department of Health ServicesMerck KGaANorthern California Institute for Research and EducationMcGill UniversityPfizerBiogenBioClinicaF. Hoffmann-La RocheEli Lilly and CompanyBristol-Myers SquibbNovartis Pharmaceuticals CorporationMeso Scale DiagnosticsCure Alzheimer's FundSanofi
KeywordsGenotypeApolipoprotein ECognitive impairmentDiseaseCognitionAssociation (psychology)
DOInot available

Abstract

fetched live from OpenAlex

Nature neuroscience 28(8), 1610 - 1621 (2025). doi:10.1038/s41593-025-02000-6

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.008
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.001
Science and technology studies0.0000.001
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.011
GPT teacher head0.289
Teacher spread0.279 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2024
Admission routes1
Has abstractyes

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