Abstract B015: Impact of sun sensitivity and ultraviolet radiation on the association between blistering sunburns and keratinocyte carcinoma
Bibliographic record
Abstract
Abstract Importance Given the large and growing burden of keratinocyte carcinomas (KCs) in the United States, there is a pressing need to identify individuals at high risk. Objective To quantify the association between KC risk and history of blistering sunburns in childhood and adulthood and to investigate whether individual sun sensitivity and other measures of ultraviolet radiation modify these associations. Design We examined blistering sunburns and KC risk in the nationwide U.S. Radiologic Technologists cohort study. Baseline data (1983-2005) on lifetime sunburn history and sun sensitivity traits were collected via self-administered questionnaires. Participants were followed until the diagnosis of a first primary cancer or completion of a follow-up questionnaire (2012-2014). Setting United StatesParticipants Radiologic technologists without a prior cancer who reported White race or Hispanic ethnicity and completed both the baseline and follow-up questionnaires. Exposures History of blistering sunburns before (childhood) and after (adulthood) age 15 years. Main Outcomes and Measures Risk increase for basal and squamous cell carcinoma (BCC/SCC) per blistering sunburn. Results Among 40,204 radiologic technologists (2% Hispanic; mean age at baseline:56 years), those reporting at least one blistering sunburn had a 37% higher risk of BCC and a 41% higher risk of SCC. The risk of BCC increased by 6% (95% confidence interval [95% CI], 5-7) and 5% (95% CI, 4-6) for each childhood and adulthood blistering sunburns, respectively. Similar findings were observed for SCC, with risk increasing by 8% (95% CI, 6-11) and 7% (95% CI, 5-9) for childhood and adulthood blistering sunburns, respectively. These associations were not significantly modified by most individual sun sensitivity traits and other measures of ultraviolet radiation. Conclusions and Relevance Individuals with ≥5 blistering sunburns occurring across varying ages of exposure appear to be at particularly high risk for KCs and may benefit from heightened skin cancer surveillance. Citation Format: Belinda L. Gorsuch, Jim Z. Mai, Martha S. Linet, Michael R. Sargen, Mark P. Little, Bruce H. Alexander, Cari M. Kitahara, Elizabeth K. Cahoon. Impact of sun sensitivity and ultraviolet radiation on the association between blistering sunburns and keratinocyte carcinoma [abstract]. In: Proceedings of the AACR Special Conference in Cancer Research: The Rise in Early-Onset Cancers—Knowledge Gaps and Research Opportunities; 2025 Dec 10-13; Montreal, QC, Canada. Philadelphia (PA): AACR; Clin Cancer Res 2025;31(23_Suppl):Abstract nr B015.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.005 | 0.003 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".